The Dem Love-Hate Relationship with Senator Lieberman ...

Connecticut?s Courant has this as part of a lengthy article regarding the retiring Jewish Senator Joe Lieberman: Lieberman?s evolution over the years brought him a series of new friends and supporters, including McCain, Bush, and Fox News commentator Sean Hannity. It also brought him a small army of political enemies who coalesced around a previously unknown anti-war candidate named Ned Lamont to defeat Lieberman in the 2006 U.S. Senate primary.

But Lieberman says he was vindicated with his greatest political victory in November 2006, made possible by a coalition largely made up of Republicans and independents. That proved to be his final campaign in a career that is now closing after 40 years in public service, including 24 years in the U.S. Senate.

In Connecticut, many liberal Democrats increasingly soured on Lieberman?s hawkish stances on defense and his support of Republican views. He was at his peak when he made history as the first Jewish American on a major party ticket, but his later views on the war in Iraq prompted many Democrats to deride him as a controversial and divisive figure.

Lieberman supporters believe that it was the Democratic Party ? more than Lieberman ? that changed through the years, as evidenced by the party?s blistering opposition to the Iraq war.

Lieberman himself attributed the change to ?a very unusual series of events in which I had different opportunities? involving ?different times and different people and different relationships that I had,? including his close friendship with McCain?

At the other end of the spectrum, hard-core liberals and some true-blue Democrats regret voting for Lieberman in his earlier days and say they would never do so again.

Consumer activist Ralph Nader says that Lieberman turned into ?a right-wing extremist on everything except the environment and gay rights? in the Senate.

?He started out as a promising environmentalist when he was a junior senator, and he turned into one of the leading warmongers for the American empire and an uncritical advocate for the military industrial complex that President Eisenhower warned us about,? Nader said in an interview. ?He never met a weapon system that he didn?t like. ? Look how Lieberman betrayed his own party. I?m not a fan of the Democratic Party. This is a guy who stood at the Republican National Convention, next to McCain. He supports the opponent. He describes Obama as immature, inexperienced. He comes back to the Senate, and they give him his chairmanship back!?

Despite the public clashes with friends, Lieberman has always rebounded. Even though Lieberman supported McCain over Obama in 2008, it was Obama who stepped in and said Lieberman should remain as the chairman of the Senate homeland security committee at a time when some Democrats were still angry. Although Lieberman was the first Senate Democrat to publicly scold then-President Bill Clinton in a memorable speech on the Senate floor during the Monica Lewinsky scandal in 1998, it was Clinton who traveled to Waterbury eight years later to rally support for Lieberman when he was on the ropes in the bitter primary. Clinton told the crowd that day that Lieberman was his longtime friend, and ?I love him.?

Source: http://gestetnerupdates.com/2012/12/30/the-dem-love-hate-relationship-with-senator-lieberman/

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Michigan State edges TCU 17-16 in BWW Bowl

Michigan State running back Le'Veon Bell (24) is tripped up by TCU cornerback Kevin White (25) during the first half of the Buffalo Wild Wings Bowl NCAA college football game, Saturday, Dec. 29, 2012, in Tempe, Ariz. (AP Photo/Matt York)

Michigan State running back Le'Veon Bell (24) is tripped up by TCU cornerback Kevin White (25) during the first half of the Buffalo Wild Wings Bowl NCAA college football game, Saturday, Dec. 29, 2012, in Tempe, Ariz. (AP Photo/Matt York)

Michigan State safety Isaiah Lewis (9) intercepts a pass against TCU during the first half of the Buffalo Wild Wings Bowl NCAA college football game, Saturday, Dec. 29, 2012, in Tempe, Ariz. (AP Photo/Matt York)

TCU running back B.J. Catalon (23) gains yards as Michigan State Spartans defensive end William Gholston (2) defends during the first half of the Buffalo Wild Wings Bowl NCAA college football game, Saturday, Dec. 29, 2012, in Tempe, Ariz. (AP Photo/Matt York)

TCU coach Gary Patterson, right, shouts at quarterback Trevone Boykin, left, as Boykin walks off the field against Michigan State during the first half of the Buffalo Wild Wings Bowl NCAA college football game Saturday, Dec. 29, 2012, in Tempe, Ariz. (AP Photo/Paul Connors)

TCU Frogs quarterback Trevone Boykin (2) throws against Michigan State during the first half of the Buffalo Wild Wings Bowl NCAA college football game, Saturday, Dec. 29, 2012, in Tempe, Ariz. (AP Photo/Matt York)

TEMPE, Ariz. (AP) ? Michigan State labored on offense throughout the first half, unable to get anything going on the ground, in the air, anywhere.

For a team that had lost five games by a combined 13 points during the regular season, it was starting to feel familiar.

The Spartans changed their luck by turning to brutally effective running back Le'Veon Bell in the second half, setting up Dan Conroy for another game-winning kick in a bowl game.

Bell ran for 145 yards and a fourth-quarter touchdown, Conroy kicked a 47-yard field goal with 1:01 left and Michigan State rallied to beat Texas Christian 17-16 in the Buffalo Wild Wings Bowl on Saturday night.

"With so many close games and losing like we did during the season, to have one go our way was definitely sweet," Conroy said.

It wasn't always pretty for the Spartans.

Michigan State (7-6) managed 76 yards of offense during the first two quarters as TCU bottled up Bell.

The 237-pound junior started to wear down the Horned Frogs in the second half, grinding out 107 of his yards on a 32-carry night.

Behind Bell, the Spartans went on the longest drive in their bowl history in the third quarter, marching 90 yards to set up freshman Connor Cook's 15-yard touchdown pass to Aaron Burbridge.

Michigan State then recovered a muffed punt by TCU's Skye Dawson at the 4-yard line midway through the fourth and Bell scored two plays later by racing around left end for a 14-13 lead.

TCU (7-6) still had a little life after blowing a 13-point halftime lead, moving just far enough to set up Jaden Oberkrom for the longest field goal in the bowl's history, a 53-yarder that put the Horned Frogs up 16-14 with 2:42 left.

They just left Michigan State too much time.

Starting at their own 25-yard line, the Spartans moved 45 yards in eight plays, setting up Conroy for his second game-winner in a bowl after beating Georgia with a 28-yarder in the third overtime of the 2012 Outback Bowl.

Michigan State's defense held after that, sending the Spartans to their second straight bowl win after three consecutive losses.

"There was no doubt in my mind that after so many losses in similar fashion that we were going to come out on top in this one," Spartans linebacker Max Bullough said.

The Horned Frogs shut down Michigan State's offense in the first half and did just enough when they had the ball to put together three scoring drives.

In the second half, TCU couldn't get anything going against the Spartans' defense ? 84 total yards ? and its defense gave up the long scoring drive in the third quarter, along with the game-winner in the fourth.

Trevone Boykin threw for 201 yards and an interception on 13-of-29 passing for the Horned Frogs.

"A little bit empty feeling inside because we felt like we left a lot on the field," TCU coach Gary Patterson said.

TCU and Michigan State came to the desert with an awful lot of similarities.

The Horned Frogs opened their first season in the Big 12 with four straight wins before losing four of their final six games. Michigan State started 4-2, then lost four of six down the stretch.

Michigan State had the nation's fourth-best defense and was 10th in scoring defense during the regular season. TCU was 18th in total defense and 10th against the run.

Michigan State quarterback Andrew Maxwell was up-and-down in his first season as Kirk Cousins' replacement, throwing 13 touchdown passes and nine interceptions. Boykin took over after four games for Casey Pachall, who was suspended and later left the team, and threw for 15 touchdowns and nine interceptions.

The biggest difference between the teams was Bell.

He ranked third nationally with 137.3 yards rushing per game and had 1,648 on the season, second-most in Michigan State history and 242 fewer than TCU had as a team.

Early on, the Horned Frogs gave him nowhere to go.

Filling holes inside and stringing plays out toward the sidelines, TCU stuffed the bruising Bell on nearly every touch, holding him to 38 yards on 11 carries in the first half.

Of course, it didn't seem to matter what Michigan State did. The Spartans had 29 yards on 12 plays in the first quarter and weren't a whole lot better in the second, with Maxwell throwing two near-interceptions on consecutive passes and an ill-advised trick play that probably should have resulted in a turnover, too.

The Spartans still seemed to be stuck in the ruts in the third quarter before grinding out a 14-play scoring drive led by Cook, who replaced Maxwell for the second time in the game. They had their biggest play on a floating pass from Bell to fullback TyQuan Hammock (29 yards), then Cook threw his first career touchdown pass, a 15-yarder to Burbridge on a crossing route that cut TCU's lead to 13-7.

"I thought Connor did a good job on the 90-yard drive, gave us a little momentum," Spartans coach Mark Dantonio said.

TCU didn't exactly have its way with Michigan State's defense in the first half and missed some chances to build a bigger lead.

The Frogs started gashing the Spartans for decent-sized chunks with their option midway through the first quarter, setting up Matthew Tucker's 4-yard touchdown on an end-around.

Boykin had an impressive off-the-back-foot throw to freshman Kolby Listenbee for 59 yards on the last play of the first quarter and nearly had a 19-yard touchdown pass to open the second, but LaDarius Brown was bumped and dropped the ball in the end zone. Oberkrom followed with a 47-yard field goal and added another from 31 yards after Boykin hit Josh Boyce on a 61-yard pass to put TCU up 13-0 at halftime.

The Frogs couldn't keep it up in the second half.

With Michigan State clogging the running lanes and chasing Boykin around, TCU had 30 yards of offense in the third quarter and continued to struggle in the fourth. The Horned Frogs did manage the short scoring drive to set up Oberkrom's late field goal, but ended up going backward on their final drive after Conroy's kick.

"What I thought happened in the third quarter was Michigan State dialed up the heat and we didn't have an answer," Patterson said.

Michigan State did ? for one of the few times this season.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-12-30-Buffalo%20Wild%20Wings%20Bowl/id-7e72840a3dfc49f383a03959d0ab1762

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Synchronoss Buys RIM Unit, News Corp Buys OH Sports Network: Mergers and Acquisitions Recap

Synchronoss Technologies (NASDAQ:SNCR) purchases NewBay, a wholly owned subsidiary of Research in Motion Limited (NASDAQ:RIMM), for $55.5 million in cash with no assumption of cash or debt.?The transaction closed at the end of the fourth quarter. The buyer is a?mobile innovation firm which supplies activation and mobile content management solutions for connected devices.?NewBay is a leader in cloud services, permitting mobile operators and service providers to deliver content experiences across connected devices like smartphones, tablets, PCs and TVs.

On Friday, Tower International (NYSE:TOWR) said that it divested its?wholly-owned Korean subsidiary to the?privately-owned auto parts supplier?SECO. Included with the subsidiary were?5 manufacturing plants, a tooling plant, and a headquarters/tech center. Tower is a?leading integrated worldwide manufacturer of engineered structural metal components and assemblies and the move was?in order to strengthen its overall business and realize shareholder value.

Are these stocks a buy or sell? Let us help you decide. Check out our Stock Picker Newsletter now.

The Allied Pilots Association membership of American Airlines?says that their carrier?s planned merger with US Airways Group (NYSE:LCC) might not come about during the bankruptcy of the former unless pilot groups of the carriers can agree on interim contract terms. President Keith Wilson of the union said that if an agreement is not made in the very near future, in all likelihood, there will be no merger before American Airlines exits restructuring.

News Corporation (NASDAQ:NWSA) has acquired SportsTime Ohio, a regional sports network based in Cleveland that broadcasts Cleveland Indians baseball games. Although financials were not reported, an inside source estimated that the transaction was worth around $230 million, a figure that Reuters first reported on December 3rd.

Don?t Miss: The Dogs of the Dow Fall Behind.

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Source: http://feedproxy.google.com/~r/WallStCheatSheetTrading/~3/qruRBv6bKNc/

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Eversense smartphone controlled thermostat uses GPS to know when to change temps

We’ve been seeing quite a few WiFi controlled thermostats this year. I’m still using the Venstar ColorTouch thermostat which I installed this past summer. It does everything I need a thermostat to do including remote control via a smartphone or tablet. But the Eversense thermostat from Allure Energy takes things to another level. It uses [...]

Source: http://the-gadgeteer.com/2012/12/29/eversense-smartphone-controlled-thermostat-uses-gps-to-know-when-to-change-temps/

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Hinting at war crimes charges, UK minister attacks Israel for East Jerusalem construction plans

A British minister on Thursday harshly condemned Israel for its plans to expand construction in East Jerusalem and for conferring university status on a college in the West Bank city of Ariel, employing damning language rarely used by government officials.

While international outcries following Israeli announcements of construction beyond the Green Line are a common occurrence, UK Minister for the Middle East Alistair Burt took the unusual step of mentioning the Geneva Conventions, likely implying that settlement expansion is considered a war crime under international law.

The move is being seen by some as an intensification of rhetoric in response to Israel?s increasingly aggressive avowals to broaden its settlement enterprise.

In his statement, Burt said he and Foreign Secretary William Hague last week expressed ?condemnation and deep disappointment? at the Jerusalem District Planning and Building Committee?s approval of 1,500 housing units in Ramat Shlomo. They also denounced recently announced plans for additional construction in the Givat Hamatos and Gilo neighborhoods, which are beyond the Green Line.

?These are further profoundly provocative actions that run contrary to the Fourth Geneva Convention,? Burt?stated. ?By taking these steps, despite the international community repeatedly raising our profound concerns, the Israeli government is damaging Israel?s international reputation.?

Article 49 of the Fourth Geneva Convention states that an occupying power ?shall not deport or transfer parts of its own civilian population into the territory it occupies.? This is the basis for the position of international bodies, such as the United Nations and the European Union, to consider Israeli settlements beyond the Green Line illegal under international law.

Violations of the 1949 Geneva Convention are considered war crimes under international law. Israel is a party to the convention and therefore bound by its obligations.

According to pro-Israel advocate Irwin Cotler, a former Canadian justice minister and expert on international law,?Burt?s evoking of the Geneva Convention marks a ?gradual ratcheting up? of criticism in light of Israel?s increasingly assertive settlement policy. While international human right activists have in the past quoted the convention to incriminate Israel, Western government officials have generally refrained from mentioning it in relation to Israeli settlements.

?At first the settlements were unhelpful, then they became an obstacle to peace; from there they went to being illegal, from there to being contrary to international law, and now they are violating the Geneva Conventions,? Cotler told The Times of Israel. ?It seems that this signifies a calibrated indictment reciprocal to the increasing affirmations of the Israeli government?s settlement policy.?

Foreign Ministry spokesman Yigal Palmor called the word choice ?disappointing.?

?The Palestinian interpretation of the applicability of the Fourth Geneva Convention to the West Bank and to settlements therein is highly controversial and stands in contradiction with a great number of legal opinions by leading experts,? Palmor said. ?It is therefore disappointing to see that a [UK Foreign Office] minister should adopt the contested Palestinian position hook, line and sinker, thus adding controversy where it is already in excess.?

In trying to fend off such attacks, Israel usually refers to a clause in the convention that says regulations only apply to ?High Contracting Parties? ? in other words, signatory states. Since the West Bank and East Jerusalem were not within the recognized territory of any contracting party when Israel captured them, they are to be considered disputed territories rather than occupied, Jerusalem argues.

In May, the EU foreign ministers released a statement mentioning ?the applicability of the fourth Geneva Convention relative to the protection of civilians.? This passage seems to refer mostly to Israel?s obligation to safeguard Palestinians living under Israeli military control. On December 10, the EU issued a harshly worded rebuke of Israel?s plans to expand settlements in the West Bank but failed to mention the convention.

Burt, a Conservative, also called on the Israeli government to ?urgently? reverse?its decision to upgrade the Ariel University Center to a full-fledged university. ?Ariel is beyond the Green Line in a settlement that is illegal according to international law. This decision will deepen the presence of the settlements in the Palestinian territories and will create another obstacle to peace,? he said.

The minister further said that the United Kingdom appreciates the Palestinian leadership?s ?measured response? to Israel?s recent announcements and commended Palestinian Authority President Mahmoud Abbas for publicly rejecting recent ?inflammatory statements? by Hamas leaders.

Having received nonmember observer state status at the United Nations in late November, the Palestinians are said to be considering turning to the International Criminal Court in The Hague to denounce Israel for alleged war crimes relating to settlements.

However, Prime Minister Benjamin Netanyahu and other senior government ministers have repeatedly vowed to keep building despite all pressure.

Source: http://www.timesofisrael.com/hinting-at-war-crimes-charges-uk-minister-attacks-israel-for-east-jerusalem-construction-plans/

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Vicc es Vicc ? Your Experienced Location for Heating and Air ...

Hiring a skilled professional who uses the high-quality materials and understands heating and AC system is the most important thing if you need repairs in your home. There are many types of furnaces that all have distinct parts and functions. Depending on the type of home you live in, your utility bill and home temperature can improve greatly if you select an appropriate furnace. Air conditioning systems are also quite different and it is essential to install one that is the most effective. When you hire a heating and cooling specialist, they will analyze your home and help choose the system that will meet your needs the best. These specialists are also skilled in completing all varieties of repairs on these systems. Notice a large change in your year-round comfort with quality heating and cooling technicians by your side. Heating Furnace Repair Utah

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The Social Gift-Giving Wars ? Which One Looked Best For The Holiday Season?

With the holiday season upon us, let's take a look at some of the gift-giving services and how well they work, writes contributor Natasha Starkell. Facebook?s acquisition of Karma earlier this year must have caused quite a few sighs and fading hopes of the gift-giving websites, and Giftiki was even acquired by LaunchRock a couple of months ago. Yet Facebook Gifts differs from other gift services in how much freedom both the giver and recipient of the present have to select the from the gift options.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/vHKYOKdMMjw/

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PFT: Newton fined $21K for bumping official

AP

A decade ago, Cyrus Mehri and the late Johnnie Cochran demonstrated that the NFL was doing a poor job of giving African-American coaches fair opportunities to progress to the highest levels of the sport.? Mehri and Cochran made such a compelling case that the NFL installed the ?Rooney Rule,? which requires at least one minority candidate to be interviewed for every head-coaching vacancy.

Today, only a minority of head coaching jobs are filled by members of minority groups, with five African-American head coaches (Marvin Lewis, Mike Tomlin, Romeo Crennel, Lovie Smith, Leslie Frazier) and one Hispanic head coach (Ron Rivera).? That?s six, out of 32.

As Michael Silver of Yahoo! Sports explains, only one of 32 teams has an offensive play-caller who also is African-American.? And as of a few weeks ago, the number was zero; Jim Caldwell inherited those duties in Baltimore once Cam Cameron was fired.

?We are very, very conscious of this issue, and it?s something that needs to be addressed,? John Wooten, chairman of the Fritz Pollard Alliance, told Silver. ?We have alluded to it and spoken to it directly, and we feel our only course of action is to push more people up the pipeline.?

And that seems to be the biggest problem.? African-American coaches aren?t being positioned to naturally mature into the role of play-caller on offense.?Really, the reason why there aren?t a lot of guys calling plays is that you have to have people ascending to quarterbacks coach and jobs that lead to coordinator positions.? And that?s simply not happening,? Bengals coach Marvin Lewis told Silver.? ?There are a lot of good coaches who aren?t getting those opportunities.?

As Silver points out, only two NFL quarterbacks coaches are African-American:? Karl Dorrell of the Texans and Craig Johnson of the Vikings.? Curtis Modkins serves as offensive coordinator in Buffalo, but head coach Chan Gailey calls the plays.

?This is the biggest travesty that?s taking place in this league, and every black coach is well aware of it,? an anonymous African-American assistant for an AFC team told Silver.? ?They don?t promote you from running backs coach or receivers coach to offensive coordinator.? When guys do get coordinator titles, they have to be position coaches at the same time, and they don?t get paid as much as other coordinators, because they?re not the play-callers.? And in a lot of cases, guys believe they?re really there for locker-room reasons, to ?take care of? the minority players.?

Eventually, the absence of a pipeline of African-American offensive minds will make it hard to find viable African-American head coaches, since all current minority head coaches have defensive backgrounds.

?The whole thing we have to do in terms of building this pipeline is make teams more conscious of the fact that [position coaches] want to get involved,? Wooten said. ?I tell these running backs, receivers and quarterbacks coaches, ?Go to the head coach and general manager and tell them you want this as an opportunity to learn.?? You learn by being in game plan meetings, when plays are being installed.? You listen and learn.?

Real change may come only if the Rooney Rule, which since its adoption has been extended to G.M. positions, is also applied to coordinator jobs.? However, Wooten isn?t recommending that.

?I just feel that the head coach has to have the right to select his people,? Wooten said.? ?If they can?t see who?s the best out there for them, they?re gonna perish anyway.?

Wooten is right, but the Rooney Rule doesn?t require minority candidates to be hired.? It only requires them to be considered, an important reality given that head coaches immediately tap into their network of friends, cronies, and (sometimes) family members when filling out their staffs.? If nothing else, requiring coaches to interview at least one minority coordinator candidate will help position coaches become better prepared to interview for coordinator positions ? and eventually to get them.

In the end, it?s a simple analysis.? If the NFL believes the Rooney Rule remains viable ten years later when the number of minority head coaches has expanded to six, the NFL should take a hard look at whether the Rooney Rule should be applied one level lower, given that the number of minority play-callers is one and, as of the first of the current month, it was zero.

Source: http://profootballtalk.nbcsports.com/2012/12/27/report-newton-fined-21000-for-bumping-referee/related/

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Works and Days ? An Anatomy of a Most Peculiar Institution

A Campus-full of Contradictions

Almost everything about the modern university is a paradox. It has become a sort of industry gone rogue that embraces practices that a Wal-Mart or Halliburton would never get away with. It is exempt from scrutiny in the fashion that the Left ceased talking about renditions or Guantanamo Bay once Barack Obama was elected, or a Code Pink goes after a NRA official in the way it would never disrupt a hearing on Fast and Furious. In other words, the university is one of the great foundations of the Left, and so is immune from the sort of criticism that otherwise is daily leveled against other institutions.

So let?s take a 10-minute stroll through the campus and learn why costs soar even as students are ever more poorly educated.

The Curriculum

A student?s life on campus is a zero-sum game. For each elective like ?The modern comic book,? or ?Chicana feminisms? or ?Queering the text,? students have no time (or desire to) take more difficult and instructive classes on the British Enlightenment or A History of World War I or Classical English Grammar. (Yes, despite the relativist, anti-hierarchical university, concepts really do exist ?like ?more instructive.?) The former are mostly therapeutic classes, entirely deductive, in which the point is not to explore an intellectual topic by presenting the relevant facts and outlining the major controversies, while sharpening students? inductive reasoning and empirical objectivity, as well as improving their English prose style and mastering grammar and syntax in their written work.

The result is perhaps a fourth of the liberal arts courses ? many would judge more like 50% ? would never have been allowed in the curriculum just 40 years ago. They tend to foster the two most regrettable traits in a young mind ? ignorance of the uninformed combined with the arrogance of the zealot. All too often students in these courses become revved up over a particular writ ? solar power, gay marriage, the war on women, multiculturalism ? without the skills to present their views logically and persuasively in response to criticism. Heat, not light, is the objective of these classes.

Why are these courses, then, taught?

For a variety of practical reasons: 1) often the professors are rehashing their doctoral theses or narrow journal articles and are not capable of mastering a wider subject (e.g., teaching a class in ?The Other in Advertising? ?is a lot easier than a systematic history of California); 2) the quality of today?s students is so questionable that the social sciences have stepped up to service the under-qualified, in the sense of providing courses, grades, and graduation possibilities; 3) the university does not see itself as a disinterested nexus of ideas, where for a brief four years students are trained how to think, given a corpus of fact-based knowledge about their nation and world, and expected to develop an aesthetic sense of art, music, and literature. Instead college is intended as a sort of boot camp for the progressive army, where recruits are trained and do not question their commissars.

So the new curriculum in the social sciences and humanities fills a need of sorts, and the result is that today?s graduating English major probably cannot name six Shakespearean plays; the history major cannot distinguish Verdun from Shiloh; the philosophy major has not read Aristotle?s Poetics or Plato?s Laws; and the political science major knows very little of Machiavelli or Tocqueville ? but all of the above do know that the planet is heating up due to capitalist greed, the history of the United States is largely a story of oppression, the UN and the EU offer a superior paradigm to the U.S. Constitution, and there are some scary gun-owning, carbon-fuel burning, heterosexual-marrying nuts outside the campus.

If we ask why vocational and tech schools sprout up around the traditional university campus, it is because they are upfront about their nuts-and-bolts, get-a-job education: no need to worry about ?liberal arts? or ?the humanities? ? especially given that the universities? General Education core is not very general and not very educational any more. Yes, I am worried that the University of Phoenix graduate has not read Dante, but more worried that the CSU Fresno graduate has not either, and the former is far more intellectually honest about that lapse than the latter.

Note here the illiberal nature of allowing highly paid faculty to indulge their curricular fantasies at the expense of indebted students who pay a great deal for a great deal of nothing. Is there a provost or a dean in America that can say to faculty, ?That is not a real course, and so won?t be taught at our real university?? Does the shop foreman let the welder choose his own project?

Source: http://pjmedia.com/victordavishanson/a-most-peculiar-institution/

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Samsung confirms multi-window feature and Jelly Bean update for original Galaxy Note

That previously-spotted Premium Suite upgrade for the Galaxy Note is on its way, with Samsung revealing all the details on its site. With a refreshed UI appears very similar to its successor, the respectable Android slab will also lay claim to Air View, Multi-window apps and the addictive easy clip function that allows you to crop and share images and text with the stylus. Thanks to that Jelly Bean update, owners of Samsung's original phablet can also start dabbling with Google Now, which will continue to pluck information from your search history, location and timezone. There's no word yet on when the refreshed Premium suite will find its way onto devices anywhere, but with Samsung already singing the update's praises, it shouldn't be far away.

[Thanks Kenneth]

Filed under: Cellphones, Software, Mobile, Samsung

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Source: http://www.engadget.com/2012/12/27/samsung-galaxy-note-confirms-multi-window-jelly-bean-update/

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People with mental disorders more likely to have experienced domestic violence

Dec. 26, 2012 ? Men and women with mental health disorders, across all diagnoses, are more likely to have experienced domestic violence than the general population, according to new research from King's College London's Institute of Psychiatry, in collaboration with the University of Bristol. Previous studies into the link between domestic violence and mental health problems have mainly focused on depression, but this is the first study to look at a wide range of mental health problems in both male and female victims.

In this study, funded by the National Institute for Health Research (NIHR) and published December 26 in PLOS ONE, researchers reviewed data from 41 studies worldwide. Compared to women without mental health problems, women with depressive disorders were around 2 and a ? times more likely to have experienced domestic violence over their adult lifetime (prevalence estimate 45.8%); women with anxiety disorders were over 3 and a ? times more likely (prevalence estimate 27.6%); and women with post-traumatic stress disorder (PTSD) were around 7 times more likely (prevalence estimate 61.0%).

Women with other disorders including obsessive compulsive disorder (OCD), eating disorders, common mental health problems, schizophrenia and bipolar disorder were also at an increased risk of domestic violence compared to women without mental health problems. Men with all types of mental disorders were also at an increased risk of domestic violence. However, prevalence estimates for men were lower than those for women, indicating that it is less common for men to be victims of repeated severe domestic violence.

Professor Louise Howard, senior author of the study from King's Institute of Psychiatry, says: "In this study, we found that both men and women with mental health problems are at an increased risk of domestic violence. The evidence suggests that there are two things happening: domestic violence can often lead to victims developing mental health problems, and people with mental health problems are more likely to experience domestic violence."

This study is part of PROVIDE, a 5-year research programme on domestic violence funded by NIHR. Professor Gene Feder, co-author of the study from the University of Bristol's School of Social and Community Medicine and chief investigator of PROVIDE says: "We hope this review will draw attention to the mental health needs of survivors of domestic violence and remind general practitioners and mental health teams that experience of domestic violence may lie behind the presentation of mental health problems."

Internationally, the lifetime prevalence of physical and/or sexual partner violence among women ranges from 15-71%. In the UK, the2010/11 British Crime Survey reported that 27% of women and 17% of men had experienced partner abuse during their lifetime, with women experiencing more repeated and severe violence than men. From March 2013, the UK Home Office will be amending its definition of domestic violence to include 16 and 17 year olds, and will be defined as "any incident or pattern of incidents of controlling, coercive or threatening behaviour, violence or abuse between those aged 16 or over who are or have been intimate partners or family members regardless of gender or sexuality. This can encompass, but is not limited to, psychological, physical, sexual, financial or emotional abuse."

Professor Howard concludes: "Mental health professionals need to be aware of the link between domestic violence and mental health problems, and ensure that their patients are safe from domestic violence and are treated for the mental health impact of such abuse."

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The above story is reprinted from materials provided by King's College London, via EurekAlert!, a service of AAAS.

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Journal Reference:

1. Kylee Trevillion, Si?n Oram, Gene Feder, Louise M. Howard. Experiences of Domestic Violence and Mental Disorders: A Systematic Review and Meta-Analysis. PLoS ONE, 2012; 7 (12): e51740 DOI: 10.1371/journal.pone.0051740

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/bCELOUB9SrA/121226223049.htm

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New insight into cell development and cancer

Dec. 27, 2012 ? Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

The study, published December 27, 2012 by the journal Molecular Cell, implicates a unique class of proteins called polycomb-like proteins, or PCL's, as bridging molecules between the "on" and "off" state of a gene. While all of these specialized types of cells share the same genetic information encoded in our DNA, it is becoming increasingly clear that information outside the genome, referred to as epigenetics, plays a central role in orchestrating the reprogramming of a stem cell down a defined path.

Although it is understood that epigenetics is responsible for turning genes "on" and "off" at defined times during cellular development, the precise mechanisms controlling this delicate process are less well understood.

"This finding has important implications for both stem cell biology and cancer development, as the same regulatory circuits controlled by PCL's in stem cells are often misregulated in tumors," said Dr. Greg Wang, senior author of the study and Assistant Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center.

The study, led by postdoctoral research fellows Drs. Ling Cai and Rui Lu in the Wang lab, and Dr. Scott Rothbart, a Lineberger postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center, identified that PCL's interact with an epigenetic signal associated with genes that are turned on to recruit a group of proteins called the PRC2 complex which then turn genes off.

"In stem cells, the PRC2 complex turns genes off that would otherwise promote reprogramming into specialized cells of organs like the heart or lungs," said Wang.

In addition to its fundamental role in cellular development, elevated levels of PRC2 have been found in cancers of the prostate, breast, lung, and blood, and pharmaceutical companies are already developing drugs to target PRC2. Wang and colleagues determined that the same mechanisms controlling PRC2 function in stem cells also applies in human cancers.

"The identification of a specific PCL in controlling PRC2 in cancer cells suggests we may be able to develop drugs targeting this PCL to regulate PRC2 function in a more controlled manner that may maintain PRC2 function in stem cells while inhibiting it in the tumor," said Wang.

This research was funded by the National Institutes of Health grants (GM085394 and GM068088), the Department of Defense, the V Foundation for Cancer Research, and the University Cancer Research Fund, and was performed in collaboration with scientists at the University of California at Riverside, Rockefeller University, Memorial Sloan-Kettering Cancer Center, and the Albert Einstein College of Medicine. Study co-authors from UNC also included Bowen Xu, a student in the Wang Lab, and Ashutosh Tripathy, a Research Professor in the Department of Biochemistry and Biophysics.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/g5nZCwhyrsQ/121227130323.htm

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What Women Should Know About Estate Planning

Caring for yourself is a top priority. ?A durable power of attorney allows you to appoint someone you trust to make legal and financial decisions for you when you cannot.

Everyone has an estate and needs a plan.? An estate is simply what you own when you die ? a home, bank accounts, investments, personal property.? A will or living trust enables you to determine who will receive those assets.

There?s a different between a will and a living trust.? A will does not take effect until you die; a living trust can hold assets for your benefit while you are alive.

Trusts are not just for the wealthy.? A trust can be a good way to achieve your goals, even if you?re not rich ? including protecting assets from creditors and ex-spouses.

Spouses get additional tax breaks. ?Assets that are received as gifts or inherited are not taxed, and a surviving spouse can add a deceased spouse?s unused estate tax exclusion to her own.

Once widowed, tax planning is more important.? When one spouse dies, the unlimited marital deduction no longer applies, but there are still a number of tax-saving strategies surviving spouses can use to preserve assets.

You shouldn?t own your own life insurance policy.? To avoid taxes, your life insurance policy should be owned by the beneficiary or by a trust.

Fill out beneficiary forms and keep them updated.? Retirement accounts are distributed to whomever is listed on a beneficiary form, and that form trumps a will bequest.

Keep cash on hand.? Cash is crucial to cover expenses should a spouse suddenly die; keep a joint account for this purpose.

An experienced Annapolis estate planning attorney can help you understand all your options for estate planning.? Experienced Estate Planning Attorney Seth B. Zirkle can discuss all your options and create a plan with you.? Call Mr. Zirkle at Hyatt & Weber, P.A. today at 410-505-4553.

Source: http://hyattweberestateplanning.com/estate-planning/what-women-should-know-about-estate-planning/

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Nubia Z5 unveiled in China with quad-core chip, 5-inch 1080p display and 7.6mm thickness

Much like many Chinese smartphone brands these days, ZTE sub-brand Nubia had prematurely given away the main selling points of its Z5 ahead of its Beijing launch today, but there were still some surprises. As you probably already know, here's yet another five-inch 1080p Android phone featuring Qualcomm's 1.5GHz quad-core APQ8064, 2GB RAM and 32GB of internal storage, along with a 13-megapixel F2.2 main camera (with five-element optics by Konica Minolta, plus separate touch focus and touch exposure in the app) and a two-megapixel front-facing camera. For multimedia consumption, the Z5 supports WiFi Display and MHL output should you wish to beam content to a larger screen; whereas on the audio side you are spoiled with either Yamaha or Dolby Digital Plus. But wait, there's more!

Gallery: Nubia Z5 hands-on

Gallery: Nubia Z5 press event

Continue reading Nubia Z5 unveiled in China with quad-core chip, 5-inch 1080p display and 7.6mm thickness

Filed under: Cellphones, Mobile

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Source: Nubia

Source: http://www.engadget.com/2012/12/26/nubia-z5-launch/

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Mind: Understanding the Effects of Social Environment on Trauma Victims

[unable to retrieve full-text content]A significant body of work suggests that what a person experiences just after a traumatic event, particularly other people?s responses, may be just as crucial as the event itself.

Source: http://www.nytimes.com/2012/12/25/science/understanding-the-effects-of-social-environment-on-trauma-victims.html?partner=rss&emc=rss

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Use These SEO Tips To Maximize Your Site Traffic | Internet ...

With everyone online rallying for attention to their site, maximizing your SEO potential is the only way to effectively get traffic to your web business. Search engines are tools that a large number of people use to find information on just about anything. Put these strategies to use, and your site?s traffic will explode.

Search Engines

TIP! Join the BBB or the nearby Chamber of Commerce to boost your SEO. These organizations link to their member businesses, so you can get more local visitors.

Use good, descriptive text for your site?s title tag so search engines can figure out the relevance of your site?s content, and display your site in lots of search results. Search engines usually will not show content past 60 characters. Words past the 60-character point also tend to matter less to search engines. It should go without saying that original content beats out copied content in the SEO wars. To bring users to your site, you need content that?s unique and interesting. Viewers will stay on your site and come back often if you are giving them content that gives good info. Put yourself in the search seat and ponder as to what keywords you would use to locate your website. Then ensure these keywords are prominent throughout your web pages. Add keywords to both your title tag and main content, but keep your keyword density to a sane level to avoid getting the dreaded ?keyword stuffer? label.

TIP! If you are looking to climb up the search engine ranks, then provide a plethora of content, going across many different topics, but still staying within the niche. For instance, if your blog is on soccer, you could write about the latest developments in the MLS, player trades or a recent game.

If your site covers a topic that is similar to online magazines, try to make contributions to those magazines with a backlink to your website. A lot of the time, ezines are indefinitely archived. This means that the links are still active, even after years have passed. People who find your articles will still be able to click on the links and you will still get the benefit of their visits. SEO, or search engine optimization, is essential for internet marketing. Putting the proper keywords throughout your content will give you a higher ranking on search engines, giving you more traffic. This helps your site get found by people. Search engines are a great way to get extra site visitors. Make your website easy for spiders to crawl, in order to maximize your site?s search engine ranking. Make sure you tag the images on your site, because spiders are only able to read text. You keywords should be included in your description.

TIP! Make sure to have proper analytics software before you start your SEO campaign. You need to purchase and install analytics software in order to monitor the performance of your SEO tactics.

If you are managing a business website, encourage the CEO or the owner of the business to become involved online. This is your voice of your company, and your readers want to hear that. When you blog through your own site, it increases your search engine visibility. Then, more visitors will visit your website. Informative sites generally rank higher then product-only sites. Informational content will improve the way that both search engines and site visitors perceive you.

TIP! Include your chosen key phrases in your page title and throughout your site. When people locate your page through a search engine, they will see this title, so make it relevant to your site.

Make all of your titles unique and interesting, even if the content is similar. Keep titles short and to the point for the most effect. The first few words of a title are always the most important. Put forth the image of an expert in your field. Utilize your expert qualifications for the purpose of creating a successful Internet marketing program. Post a website that focuses on a specific aspect of a certain market, then choose appropriate keywords, and use SEO to promote those keywords. Always pay attention to your customers needs, make it about them and not you. Educate yourself on the different aspects of SEO, but be careful in trying to do too much at once. It is impossible to become the best at every technique, so be sure to focus on one that will yield the best results for your business.

Quantcast Scores

You need to get more visitors to your website and keep them there to increase your page rank. There is increasing evidence that the amount of time a person spends on a site (according to metrics like Quantcast scores, etc. There is more and more evidence suggesting that how long a visitor stays on a site affects their PageRank, according to Quantcast scores. One useful way to keep visitors hanging around longer is to offer discussion groups and forums. Each search engine?s bots constantly look for newly updated content, so posting to yoru blog on a consistent basis gives the bots a reason to stop by. Not only that, if your articles are really good, other people will publish your links. After an article is shared, it starts to bring in higher levels of traffic.

TIP! There are many different strategies to optimize your site for search engines. By tailoring your website to include search-friendly terms and tags, you will be able to increase your search rankings.

Learn about exactly how much experience they have. In order to make a thoroughly researched and informed decision, you need to be aware of the potential risks involved in your choice.

Anchor Text

Make sure when writing internal links and backlinks for your website that you use good anchor text. You should describe what the page is about and give a good reason for your reader to click on your anchor text link. Ensure the right text is used as the keyword, so you receive a rise in ranking. Spiders focus on keywords, so if you pick out the most appropriate keywords for your content, they will count your anchor text towards your overall relevancy. Websites that effectively utilize search engine optimization almost never use image links. Image links do not link your content to the search engines effectively. When generating keywords and key phrases, it is important that you place yourself in the shoes of the customer. Always include the simplest terms a customer would use to find your site. Successfully optimizing your site for search engines may seem intimidating, but as this article has shown you, it doesn?t have to be difficult. Knowing the few basic principles that determine how the search engines work, can help you tweak your site to attract more visitors than ever. Before you know it, you?ll have a slew of new customers.

Source: http://realworldbusiness.com/seo/use-these-seo-tips-to-maximize-your-site-traffic/

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Best Internet Marketing Business Models for Making Money Online ...

www.Rat-Race-Escape-Artists.com http Hey folks! This is Bolaji from Rat-Race-Escape-Artists.com. And you?re watching the video series ?The 10 Secrets Everyone Wants to Know About Escaping the Rat Race.? This video answers the question: What are the Best Internet Marketing Business Models for Making Money Online? The answers include: 1: Blogging with AdSense 2: The Product Launch Formula 3: The Underachiever Mastery Model 4: The Butterfly Marketing Model 5: The Membership Site (Continuity) Model 6: Affiliate Marketing 7: Cost Per Action / Lead Generation 8: Online Auctions 9: Private Label Rights 10: Flipping Web Sites Get the details on each of these nuggets of advice in this video. If you?d like the full 10-day Bootcamp on Escaping the Rat Race, visit www.Rat-Race-Escape-Artists.com, OR http Let me know what you thought about the video? and what questions you?d like me to answer next about your rat race escape! Let?s get you earning passive income in a systematic and leveraged fashion ? earning affiliate residual income, and avoiding business scams along the way. ============================================ The full video series answers the following questions: ============================================ Q1: What is the formula for making money online? Q2: How can I avoid being scammed by Internet Marketing Offers? Q3: How do I find time to build an online business? Q4: What is the cheapest way to make money online? Q5: What is the fastest way to make money online ?
Video Rating: 5 / 5

This entry was posted in Internet Marketing Business and tagged Affiliate Marketing, Best, Business, Escape, income, Internet, Making, Marketing, Models, MONEY, Online, Online Auctions, Private Label Rights, Race, Video Rating. Bookmark the permalink.

Source: http://stress-management-products.com/?p=1084

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Poetic Slimline case for Asus Google Nexus 7 review

My search for a Nexus 7 case continues. ?I’ve been down the cheap path, and then looked at the premium option, but what lies in that middle ground ? Poetic is a company makes cases for heaps of devices, and they were good enough to send me a Slimline case , one of about 10 [...]

Source: http://the-gadgeteer.com/2012/12/24/poetic-slimline-case-for-asus-google-nexus-7-review/

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Video: TODAY anchors share favorite holiday memories

Sorry, Readability was unable to parse this page for content.

Source: http://video.today.msnbc.msn.com/today/50271444/

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Heavy Pets - Culture Room, Fort Lauderdale - December 21 - Fort ...

So, the world didn't exactly come to an end on Friday. But something major definitely went down at?Culture Room, where Greenhouse Lounge and the Heavy Pets, with special guest Roosevelt Collier, jammed out an epic end-of-the world party. If any sort of an apocalypse was gonna happen, this was where we wanted to be.?

The Heavy Pets took to the stage in the most potent, assertive show we have seen from?them yet. They have become local staples, playing (much needed) afterparties around town for major acts like Umphrey's McGee, but this concert made a clear statement that they are a headlining act in their own right.

First of all, we made sure to arrive early on Friday because we missed out on Greenhouse Lounge's opening set for Papadosio a couple weeks ago, a big mistake which we were determined to rectify. The Jacksonville-based trio weave a soundscape of jam, ?jjazz, electro, and funk that proves "jamtronica" is not only a legitimate genre, but an entirely new musical frontier.?

Now, we knew that a concert headlining the Heavy Pets would be exactly as awesome as it was. But the real star of the night was Robert Collier, the steel pedal guitarist who sat in for nearly half of the Pets' set. You may have heard him around town as a member of the Lee Boys, a Miami-based soul brigade made up of an extremely talented crop of brothers and nephews. We'll call it a great case of musical genes. Collier made an appearance with the Heavy Pets last month at Bear Creek, and it went down so well that we can only assume they wanted to make it happen again just in case the world truly did implode on itself.?

Over an hour into the set, Collier joined the Heavy Pets onstage for a steelled-up medley of Heavy Pets gems, old and new: "Xylophone", "Help Me Help You," a track from the newly-released EP, The Everywhere Sessions, Vol. 1, and "Girl You Make Me Stupid," a crowd favorite that has become something of a Heavy Pets concert staple since the release of their debut double-disc album, Whale, in ?2007. "Girl You Make Me Stupid" was a highlight not only on account of Collier's presence, but also due to funky vocals and a searing solo from Jim Wuest on keyboards.

The Heavy Pets were also joined by local songstress Leiah Siciliano (who, at first beer-goggled glance, we kinda thought was Alanis Morissette), who lent her vocals to "Love Gigantic."?

The Heavy Pets have been making waves at major Florida events such as Bear Creek and Art Basel this fall, and this year has definitely marked a period of progression for the group. With backing from local tastemakers Brotherly Love Productions, the Heavy Pets have quickly become the most beloved jam band in SoFla and most certainly beyond (we're not sure how far we can extend our own personal taste, but they're awesome).?

The apocalyptic get-down closed out with a drawn-out rendition (with help from Collier) of "The Day the Sun Forgot to Rise," a new track from?The Everywhere Sessions, Vol. 1.?A nod to the apocalypse? Perhaps. But now that the world hasn't ended, we can confidently start to look forward to the Pets' next SoFla appearances. They'll spend the holidays playing up north (lame), but will return to play some excellent after parties for Jam Cruise pre- and post-shows in Fort Lauderdale.?

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Source: http://blogs.browardpalmbeach.com/countygrind/2012/12/heavy_pets_culture_room_draft.php

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HP Could Layoff At Least 70 Autonomy Employees - Business Insider

HP plans to lay off a bunch of Autonomy employees, according to several news reports.

Up to 200 Autonomy employees are bracing themselves for a pink slip, writes Jon Rees at the U.K. publication, the Daily Mail.

The actual number of cuts could be closer to 70, reports Arik Hesseldahl from AllThingsD, naming sources close to the company.? These 70 will be mostly salespeople who were hired before HP bought Autonomy.

The layoffs were reportedly in the works before HP announced an $8.8 billion writedown of Autonomy, Hesseldahl reports.?

HP claimed that $5 billion of that write-down was due to fraud in Autonomy's book. Autonomy's founder and former CEO, Mike Lynch, has adamantly denied any wrong-doing.

Word of Autonomy-specific layoffs shouldn't be surprising. In addition to the massive write-down on the value of Autonomy, HP has been involved in a multi-year effort to shed 29,000 jobs from its payroll by the end HP's 2014 fiscal year.

HP declined comment.

Source: http://www.businessinsider.com/hp-could-layoff-at-least-70-autonomy-employees-2012-12

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petermacneillgg: Arts And Entertainment: Humor Article Category ...

Because the bass player is too slow, for the winger it's too little money and the drummer didn't get the assignment. Blog readers often have the opportunity to comment on the jokes they find most funny and original.

Things are looking a lot more inspiring in this second part of the year. In this new season of fall and winter movies there should be something for everyone. There are action movies, family movies, Oscar worthy dramas, and some spicy comedies coming up in the next third of the year.

But it does. bancuri can help you to heal from depression and stress. It can even do more: if you make a habit of looking for laughter, it can even promote your long-term good health. It might even help you to find new kindred spirits with whom you can share your sense of humor. Anyone who can help you to again experience the whimsy, amusing ironies, joyfulness and chortles or even guffaws that spring out of living a positive life is worth keeping around.

Johnny Depp is the star of this movie. Intrigue, danger, and romance will become his nemesis in The Tourist, after he has a playful romance with a stranger. Frank (Depp), takes a trip to Europe to forget a bad love affair and meets Elise, with whom he involves himself in an encounter that has been engineered by Elise. A terrible game of cat and mouse ensues through Paris and Vienna as their romance evolves.

The pianists we see play appear to be the most formal and respectable stars on the stage. They hold the power and the breath of the audiences. They could look intimidating in their formal suits not to mention the authority and the air of arrogance they exude while on stage. They can be captivating.

There is an exercise I call the Pink Tu Tu tactic. Learn to use it on someone you fear, are angry at, or someone you feel has power over you. Simply visualize that person dancing in a bright neon pink Tu Tu. Guaranteed to bring a smile to your face and completely strip them of any power you thought they had over you.

There are benefits beyond the fun to this kind of silliness. Have you noticed that "going green" and saving money often involve the same behaviors? "Use it up. Wear it out. Recycle it." is good for both the environment and the pocketbook. And if you can find fun ways to do it, it's also good for your sense of well-being.

With the world going at a really crazy pace, people forget to stop and smile a bit. Most of these mistakes can be frustrating and depressing.

Source: http://luvcave.com/blog/21735/arts-and-entertainment-humor-article-category/

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Source: http://petermacneillgg.blogspot.com/2012/12/arts-and-entertainment-humor-article.html

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Source: http://briannaayers22.posterous.com/petermacneillgg-arts-and-entertainment-humor

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Source: http://tybydesybun.posterous.com/petermacneillgg-arts-and-entertainment-humor

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Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children

Dec. 23, 2012 ? Acute lymphatic leukemia (ALL) is the most common cancer in children under the age of 14 years. With optimum treatment, approximately 75 percent of children are currently cured, but the treatment consists of severe chemotherapy with many side effects. In collaboration with international research teams, scientists at VIB, KU Leuven and UZ Leuven have identified new genetic mutations that lead to T-ALL, a variant of ALL. They have unmasked the ribosome -- the molecular machine in the cell that is involved in the production of proteins -- as a weak spot in leukemia cells.

Their research has also shown that there is a difference in T-ALL between adults and children. Both findings can be important in the search for improved treatments for T-ALL.

Jan Cools (VIB/KU Leuven): "We have discovered that there is a clear genetic difference between T-ALL in children and in adults. This could be an explanation why adults do not respond as well to the current therapy."

Stein Aerts (KU Leuven): "This is a beautiful example of the power of genome sequencing in cancer research. New technologies and large-scale bio-informatics allow us to study a lot of data simultaneously. This allows us to discover links that would have been impossible to find in the past."

T-cell acute lymphatic leukemia (T-ALL)

The formation of white blood cells is disrupted by leukemia. The cells in the bone marrow that should mature into white blood cells multiply unchecked without maturing completely. These immature blood cells compromise the production of normal blood cells. This makes patients more susceptible to infections. Leukemia occurs in different forms; in the case of T-ALL, there is an accumulation of immature white blood cells over a very short period of time. With optimum treatment -- involving chemotherapy -- approximately 75 % of children are currently cured. For adults, the chance of a cure is below 50 %. Chemotherapy is associated with many side effects. The search for a more specific treatment can only start once we know what causes T-ALL.

7 new genes with a key role in T-ALL identified

T-ALL only occurs if errors in various genes occur simultaneously. It is important to determine which genes play a key role. Kim De Keersmaecker, Zeynep Kalender Atak, Jan Cools and Stein Aerts have identified a series of defects in 15 important genes, of which 7 have not previously been associated with T-ALL. They used next-generation sequencing to analyze the 20,000+ genes of 67 T-ALL patients. This technique allows for very fast analysis and comparison of the complete DNA sequence of healthy and sick individuals.

A difference between adults and children

The investigators from Leuven also discovered a difference between T-ALL in children and in adults. T-ALL in adults contains significantly more mutations than in children. The leukemia cells in adults also contain mutations in other genes than in children. This genetic difference could be a possible explanation why adults do not respond as well to the current therapy.

A weak point in leukemia cells exposed

RPL5 and RPL10 -- two newly identified genes -- form part of the ribosome: this is the complex in the cell that produces proteins. The scientists hereby demonstrated for the first time that defects in the ribosome can also play a role in cancer activation. Experiments in yeast cells confirm that mutations in RPL10 cause a change in the ribosome.

Kim De Keersmaecker (VIB/KU Leuven): "This could be a weak point of the leukemia cells: all cells need properly functioning ribosomes to survive and to grow. These 'defective' ribosomes in the leukemia cells could be a new suitable target for the development of targeted therapies."

Patient information

As this study may raise many questions in patients, we would like to refer you to the e-mail address that the VIB has set up for this purpose. Anyone with questions about this research and other medical research can submit their questions on patients@vib.be. Please submit your question in Dutch or English only.

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Journal Reference:

1. Kim De Keersmaecker, Zeynep Kalender Atak, Ning Li, Carmen Vicente, Stephanie Patchett, Tiziana Girardi, Valentina Gianfelici, Ellen Geerdens, Emmanuelle Clappier, Micha?l Porcu, Idoya Lahortiga, Rossella Luc?, Jiekun Yan, Gert Hulselmans, Hilde Vranckx, Roel Vandepoel, Bram Sweron, Kris Jacobs, Nicole Mentens, Iwona Wlodarska, Barbara Cauwelier, Jacqueline Cloos, Jean Soulier, Anne Uyttebroeck, Claudia Bagni, Bassem A Hassan, Peter Vandenberghe, Arlen W Johnson, Stein Aerts, Jan Cools. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genetics, 2012; DOI: 10.1038/ng.2508

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/t1aTr52MtSw/121223152437.htm

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Three new genetic links to colorectal cancer

Dec. 23, 2012 ? Vanderbilt-Ingram Cancer Center investigators have identified three new genetic "hotspots" linked to colorectal cancer.

These variants, reported Dec. 23 in an Advanced Online Publication in Nature Genetics, provide new insight into the biology of colorectal cancer -- and could represent new therapeutic targets for the disease.

Colorectal cancer is one of the most commonly diagnosed cancers worldwide -- and rates are particularly high in the United States and other developed countries. Genetics plays an important role in both sporadic and familial (inherited) forms of the disease. However, only about 6 percent of colorectal cancer cases are explained by the rare genetic variants known to confer high risk of colorectal cancer (as seen in familial forms of the disease).

Previous studies on the genetic basis of colorectal cancer have pinpointed several additional variants, but most of the studies were conducted in European/Caucasian populations.

"Looking at different ethnic groups is important because the genetic structures can be different enough that variants identified in one population do not explain risk in other populations," said Wei Zheng, M.D., Ph.D., MPH, an Ingram Professor of Cancer Research and senior author on the study. "Because of the difference in genetic structures and underlying environment exposures, it might be easier to discover some risk variants in studies conducted in non-European populations."

In 2009, Zheng and colleagues in several Asian countries established the "Asia Colorectal Cancer Consortium" to search for novel genetic risk factors for the disease. The consortium included populations in China, Korea and Japan.

Using an approach known as a "genome-wide association study" (or GWAS), Zheng and colleagues began searching for common variants linked to disease risk.

From genomic data obtained from 2,098 colorectal cancer cases and 5,749 controls, the researchers identified 64 variants, or "single nucleotide polymorphisms" (SNPs), that were associated with colorectal cancer.

The investigators then replicated these findings in another set of samples, narrowing down the number of disease-associated variants to four. Three of those four variants were also associated with colorectal cancer risk in a larger European sample.

"The findings from this study are relevant to both Asian and European populations," said Zheng. "Interestingly, these three susceptibility loci were not discovered in previous studies conducted in European-ancestry populations."

This study highlights the importance of conducting genetic studies in non-European populations to fully uncover the genetic basis for common diseases, including colorectal cancer, Zheng noted.

While the specific functions of these newly identified susceptibility loci are not clear yet, several important genes are located in the regions near the risk variants discovered in this study. For example, one risk variant is located near CCND2, the gene encoding cyclin D2, a member of the cyclin family of proteins that regulate the cell cycle. Cyclins have been linked to cancer, but research on the CCND2 gene has been limited. Therefore, the current findings suggest the need for further research on the role of other cyclins and cyclin-dependent kinases in carcinogenesis.

"These new discoveries are very exciting," Zheng said. "They will certainly lead to future studies regarding the biology of these regions and the translational potential of these findings in cancer prevention and treatment."

The research was supported in part by grants from the National Cancer Institute (CA070878, CA082729, CA124558, CA148667 and CA122364) of the National Institutes of Health.

Zheng is also a professor of Medicine, director of the Vanderbilt Epidemiology Center, and chief of the Division of Epidemiology at Vanderbilt University.

Other Vanderbilt authors on the paper were: Ben Zhang, Ph.D.; Qiuyin Cai, M.D., Ph.D.; Jirong Long, Ph.D.; Jiajun Shi, Ph.D.; Wanqing Wen, M.D., MPH; Gong Yang, M.D., MPH; Ryan Delahanty, Ph.D., and Xiao-Ou Shu, M.D., Ph.D.

This research was conducted in collaboration with investigators from Sun Yat-sen University Cancer Center (China), Aichi Cancer Center Research Institute (Japan), Korean National Cancer Center (South Korea), the Shanghai Cancer Institute (China), Yonsei University (South Korea), Hallym University College of Medicine (South Korea), National Cancer Institute (USA), Kyoto University Center for Genomic Medicine (Japan), and Seoul National University College of Medicine (South Korea).

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The above story is reprinted from materials provided by Vanderbilt University Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Wei-Hua Jia, Ben Zhang, Keitaro Matsuo, Aesun Shin, Yong-Bing Xiang, Sun Ha Jee, Dong-Hyun Kim, Zefang Ren, Qiuyin Cai, Jirong Long, Jiajun Shi, Wanqing Wen, Gong Yang, Ryan J Delahanty, Bu-Tian Ji, Zhi-Zhong Pan, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Yoon-Ok Ahn, Eun Jung Park, Hong-Lan Li, Ji Won Park, Jaeseong Jo, Jin-Young Jeong, Satoyo Hosono, Graham Casey, Ulrike Peters, Xiao-Ou Shu, Yi-Xin Zeng, Wei Zheng. Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer. Nature Genetics, 2012; DOI: 10.1038/ng.2505

Note: If no author is given, the source is cited instead.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/iZRRoxpFSzA/121223152624.htm

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